Issue 17, 2023

A microfluidic approach for the detection of uric acid through electrical measurement using an atomically thin MoS2 field-effect transistor

Abstract

There is a demand for biosensors working under in vivo conditions, which requires significant device size and endurance miniaturization in solution environments. We demonstrated the detection of uric acid (UA) molecules, a marker of diseases like gout, whose continuous monitoring is required in medical diagnosis. We used a field effect transistor (FET) composed of an atomically thin transition metal dichalcogenide (TMD) channel. The sensor detection was carried out in a solution environment, for which we protected the electrodes of the source and drain from the solution. A microfluidic channel controls the solution flow that can realize evaporation-free conditions and provide an accurate concentration and precise measurement. We detected a systematic change of the drain current with the concentration of the UA in isopropyl alcohol (IPA) solvent with a detection limit of 60 nM. The sensor behavior is reversible, and the drain current returns to its original value when the channel is washed with pure solvent. The results demonstrate the feasibility of applying the MoS2-FET device to UA detection in solution, suggesting its possible use in the solution environment.

Graphical abstract: A microfluidic approach for the detection of uric acid through electrical measurement using an atomically thin MoS2 field-effect transistor

Supplementary files

Article information

Article type
Paper
Submitted
14 May 2023
Accepted
29 Jun 2023
First published
30 Jun 2023

Analyst, 2023,148, 4091-4098

Author version available

A microfluidic approach for the detection of uric acid through electrical measurement using an atomically thin MoS2 field-effect transistor

M. Nasiruddin, H. Waizumi, T. Takaoka, Z. Wang, Y. Sainoo, M. S. A. Mamun, A. Ando, M. Fukuyama, A. Hibara and T. Komeda, Analyst, 2023, 148, 4091 DOI: 10.1039/D3AN00772C

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