Issue 12, 2023
From the journal:

RSC Advances

Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers†

Takahiro Ono, ORCID logo a   Kazuhito V. Tabata, ORCID logo b   Hiroyuki Noji, ORCID logo bc   Jumpei Morimoto ORCID logo *a  and  Shinsuke Sando ORCID logo *ac  

* Corresponding authors

a Department of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
E-mail: jmorimoto@chembio.t.u-tokyo.ac.jp, ssando@chembio.t.u-tokyo.ac.jp

b Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

c Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Abstract

We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.

Graphical abstract: Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

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Article information

DOI
https://doi.org/10.1039/D3RA01358H
Article type
Paper
Submitted
28 Feb 2023
Accepted
03 Mar 2023
First published
13 Mar 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 8394-8397

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Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

T. Ono, K. V. Tabata, H. Noji, J. Morimoto and S. Sando, RSC Adv., 2023, 13, 8394 DOI: 10.1039/D3RA01358H

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