Issue 13, 2023

Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones

Abstract

Cyclobutane-fused dihydropyridones can be efficiently synthesized by a completely endo-selective gold-catalyzed cyclization of alkynylcyclobutanes bearing an appended amide, which proceeds under mild conditions. The observed selectivity, which is reversed from that previously observed for the cyclization of related alcohols and acids, is supported by DFT calculations.

Graphical abstract: Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones

Supplementary files

Article information

Article type
Communication
Submitted
10 Jan 2023
Accepted
01 Mar 2023
First published
15 Mar 2023
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2023,21, 2705-2708

Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones

M. S. Garre, G. G. Otárola, E. Merino, D. Sucunza, E. Aguilar, M. T. Quirós, J. J. Vaquero and P. García-García, Org. Biomol. Chem., 2023, 21, 2705 DOI: 10.1039/D3OB00051F

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