Issue 80, 2023

A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

Abstract

We report the fluorescent nucleoside ToldU and its application as a photoresponsive crosslinker in three different DNA architectures with enhanced fluorescence emission of the crosslinked products. The fluorogenic ToldU crosslinking reaction enables the assembly of DNA polymers in a hybridization chain reaction for the concentration-dependent detection of a specific DNA sequence.

Graphical abstract: A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

Supplementary files

Article information

Article type
Communication
Submitted
04 Aug 2023
Accepted
13 Sep 2023
First published
13 Sep 2023

Chem. Commun., 2023,59, 12003-12006

A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

H. Neitz and C. Höbartner, Chem. Commun., 2023, 59, 12003 DOI: 10.1039/D3CC03796G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements