Galectin-targeting glycocalix[4]arenes can enter the cells

Miluše Vlachová; Van Nguyen Tran; Jakub Červený; František Dolníček; Lucie Petrásková; Helena Pelantová; Ondřej Kundrát; Josef Cvačka; Zuzana Bosáková; Vladimír Křen; Pavel Lhoták; Jitka Viktorová; Pavla Bojarová

doi:10.1039/D3CC02905K

Galectin-targeting glycocalix[4]arenes can enter the cells†

Miluše Vlachová,

^a Van Nguyen Tran,^b Jakub Červený,^ac František Dolníček,^b Lucie Petrásková,^a Helena Pelantová,^a Ondřej Kundrát,^b Josef Cvačka,

^d Zuzana Bosáková,^c Vladimír Křen,

^a Pavel Lhoták,^b Jitka Viktorová*^b and Pavla Bojarová

*^ae

Author affiliations

* Corresponding authors

^a Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic
E-mail: bojarova@biomed.cas.cz
Tel: +420 296442360

^b University of Chemistry and Technology Prague, Technická 5, CZ-16628 Praha 6, Czech Republic
E-mail: prokesoj@vscht.cz
Tel: +420 220444355

^c Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, CZ-12843 Praha 2, Czech Republic

^d Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, CZ-16610 Praha 6, Czech Republic

^e Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, CZ-27201 Kladno, Czech Republic

Abstract

Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.

Chemical Communications

Galectin-targeting glycocalix[4]arenes can enter the cells†

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Galectin-targeting glycocalix[4]arenes can enter the cells

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