Chemical control of phase separation in DNA solutions

Samuel Hauf; Yohei Yokobayashi

doi:10.1039/D2CC06901F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Chemical control of phase separation in DNA solutions†

Samuel Hauf

^a and Yohei Yokobayashi

*^a

Author affiliations

* Corresponding authors

^a Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan
E-mail: yohei.yokobayashi@oist.jp

Abstract

We designed a series of DNA sequences comprising a trinucleotide repeat segment and a small molecule-binding aptamer. Optimization of the DNA sequences and reaction conditions enabled chemical control of phase separation of DNA condensates. Our results demonstrate a new strategy to regulate biomolecular phase transition.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D2CC06901F
Article type: Communication
Submitted: 19 Dec 2022
Accepted: 01 Mar 2023
First published: 06 Mar 2023
This article is Open Access

Download Citation

Chem. Commun., 2023,59, 3751-3754

Permissions

Request permissions

Chemical control of phase separation in DNA solutions

S. Hauf and Y. Yokobayashi, Chem. Commun., 2023, 59, 3751 DOI: 10.1039/D2CC06901F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Chemical control of phase separation in DNA solutions†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Chemical control of phase separation in DNA solutions

Social activity

Search articles by author

Spotlight

Advertisements