Issue 25, 2022

Cu-catalyzed carboboration of acetylene with Michael acceptors

Abstract

A copper-catalyzed three-component carboboration of acetylene with B2Pin2 and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing a homoallylic carbonyl group. The reaction was robust and could be reliably performed on the molar scale. Furthermore, the resulting cis-alkenyl boronates could be converted to diverse functionalized molecules with ease.

Graphical abstract: Cu-catalyzed carboboration of acetylene with Michael acceptors

Supplementary files

Article information

Article type
Edge Article
Submitted
22 Apr 2022
Accepted
07 Jun 2022
First published
08 Jun 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 7604-7609

Cu-catalyzed carboboration of acetylene with Michael acceptors

T. Cheng, B. Liu, R. Wu and S. Zhu, Chem. Sci., 2022, 13, 7604 DOI: 10.1039/D2SC02306G

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