Issue 31, 2022

Selective desaturation of amides: a direct approach to enamides

Abstract

C(sp3)–H bond desaturation has been an attractive strategy in organic synthesis. Enamides are important structural fragments in pharmaceuticals and versatile synthons in organic synthesis. However, the dehydrogenation of amides usually occurs on the acyl side benefitting from enolate chemistry like the desaturation of ketones and esters. Herein, we demonstrate an Fe-assisted regioselective oxidative desaturation of amides, which provides an efficient approach to enamides and β-halogenated enamides.

Graphical abstract: Selective desaturation of amides: a direct approach to enamides

Supplementary files

Article information

Article type
Edge Article
Submitted
19 Apr 2022
Accepted
30 Jun 2022
First published
06 Jul 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 9056-9061

Selective desaturation of amides: a direct approach to enamides

X. Li, Z. Cheng, J. Liu, Z. Zhang, S. Song and N. Jiao, Chem. Sci., 2022, 13, 9056 DOI: 10.1039/D2SC02210A

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