Assessing a sustainable manufacturing route to lapatinib

Roderick T. Stark; Dominic R. Pye; Wenyi Chen; Oliver J. Newton; Benjamin J. Deadman; Philip W. Miller; Jenny-Lee Panayides; Darren L. Riley; Klaus Hellgardt; King Kuok (Mimi) Hii

doi:10.1039/D2RE00267A

Assessing a sustainable manufacturing route to lapatinib†

Roderick T. Stark,^a Dominic R. Pye,^a Wenyi Chen,^a Oliver J. Newton,

^a Benjamin J. Deadman,

^b Philip W. Miller,

^a Jenny-Lee Panayides,

^c Darren L. Riley,

^d Klaus Hellgardt^e and King Kuok (Mimi) Hii

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, 82, Wood Lane, London W12 0BZ, UK
E-mail: mimi.hii@imperial.ac.uk

^b Centre for Rapid Online Analysis of Reactions (ROAR), Molecular Sciences Research Hub, 82, Wood Lane, London W12 0BZ, UK

^c Pharmaceutical Technologies, Future Production: Chemicals, Council for Scientific & Industrial Research (CSIR), Meiring Naude Rd, Brummeria, Pretoria, South Africa

^d Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Lynnwood Rd, Hatfield, Pretoria, South Africa

^e Department of Chemical Engineering, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK

Abstract

A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.

Reaction Chemistry & Engineering

Assessing a sustainable manufacturing route to lapatinib†

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