Issue 33, 2022

Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles

Abstract

An efficient metal-free, (NH4)2S2O8 mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C2 position of indoles. This catalytic approach represents a step-economic and convenient strategy for the oxidative dearomatization of indoles.

Graphical abstract: Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles

Supplementary files

Article information

Article type
Paper
Submitted
07 Jul 2022
Accepted
15 Jul 2022
First published
21 Jul 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 21022-21025

Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles

Y. Dong, J. Qian, X. Chen, H. Jiang, X. Li, Q. Zhou, T. Mei, Z. Shi, Z. Li and B. He, RSC Adv., 2022, 12, 21022 DOI: 10.1039/D2RA04191J

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