Issue 35, 2022, Issue in Progress
From the journal:

RSC Advances

Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151†

Jun-Pil Jang,‡a   Gil Soo Kim,‡c   Tae Hoon Oh,‡ad   Beomcheol Park,ad   Minhee Kim,ad   Gwi Ja Hwang,a   Hyeok-Won Lee,e   Jin-Gyeom Lee,e   Young-Soo Hong,ab   Jong Seog Ahn,*ab   Sung-Kyun Ko ORCID logo *ab  and  Jae-Hyuk Jang ORCID logo *ab  

* Corresponding authors

a Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea
E-mail: jangjh@kribb.re.kr

b Department of Biomolecular Science, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, Korea

c Central Research and Development, HanpoongPharm. Co., LTD., Wanju 54843, Korea

d College of Pharmacy, Chungbuk National University, Cheongju, Korea

e Biotechnology Process Engineering Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea

Abstract

Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.

Graphical abstract: Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

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Article information

DOI
https://doi.org/10.1039/D2RA04039E
Article type
Paper
Submitted
30 Jun 2022
Accepted
30 Jul 2022
First published
10 Aug 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 22360-22366

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Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

J. Jang, G. S. Kim, T. H. Oh, B. Park, M. Kim, G. J. Hwang, H. Lee, J. Lee, Y. Hong, J. S. Ahn, S. Ko and J. Jang, RSC Adv., 2022, 12, 22360 DOI: 10.1039/D2RA04039E

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