Issue 35, 2022, Issue in Progress
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RSC Advances

New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities†

Guowei Gu,‡a   Tao Zhang,‡a   Jianyuan Zhao,a   Wuli Zhao,a   Yan Tang,ab   Lu Wang,a   Shan Cen,a   Liyan Yu*a  and  Dewu Zhang ORCID logo *a  

* Corresponding authors

a Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China
E-mail: yly@cpcc.ac.cn, zhangdewuever@163.com

b School of Pharmacy, Yantai University, Yantai 264005, P. R. China

Abstract

Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1–3 were resolved by quantum chemical calculations of NMR shifts and ECD spectra. Compounds 5 and 11 showed significant anti-influenza A virus activities with IC50 values of 5.6 and 6.9 μM, respectively. Compounds 8 and 9 displayed cytotoxic activities against the MIA-PaCa-2 cell line with IC50 values of 2.6 and 2.1 μM, respectively. Compound 10 exhibited antibacterial activities against Bacillus cereus with a MIC value of 4 μg mL−1.

Graphical abstract: New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities

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Article information

DOI
https://doi.org/10.1039/D2RA02639B
Article type
Paper
Submitted
25 Apr 2022
Accepted
26 Jul 2022
First published
10 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 22377-22384

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New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities

G. Gu, T. Zhang, J. Zhao, W. Zhao, Y. Tang, L. Wang, S. Cen, L. Yu and D. Zhang, RSC Adv., 2022, 12, 22377 DOI: 10.1039/D2RA02639B

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