Iodine-mediated oxythiolation of o-vinylanilides with disulfides for the synthesis of benzoxazines

Abstract

An efficient iodine-mediated oxythiolation of o-vinylanilides with disulfides was developed. By virtue of this method, a series of thio-tethered benzoxazine derivatives were synthesized in good to excellent yields. The reaction features high yields, is metal-free, and has a wide substrate scope.