The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation†
Abstract
Planar chiral [2.2]paracyclophanes are resolved through the direct C–H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare.