Ryotaro Ota, Daichi Karasawa, Mizuki Oshima, Koichi Watashi, Noriko Shimasaki and Yoshinori Nishii
RSC Adv., 2022,12, 4635-4639
DOI:
10.1039/D2RA00499B,
Paper
Open Access Learn more..The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of niranthin.
