Issue 11, 2022, Issue in Progress

Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions

Abstract

Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al2O3 nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations.

Graphical abstract: Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions

Supplementary files

Article information

Article type
Paper
Submitted
05 Jan 2022
Accepted
10 Feb 2022
First published
23 Feb 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 6396-6402

Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions

R. A. Hernandez R., K. Burchell-Reyes, A. P. C. A. Braga, J. K. Lopez and P. Forgione, RSC Adv., 2022, 12, 6396 DOI: 10.1039/D1RA08443G

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