Issue 3, 2022, Issue in Progress

Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization

Abstract

A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.

Graphical abstract: Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization

Supplementary files

Article information

Article type
Paper
Submitted
28 Oct 2021
Accepted
13 Dec 2021
First published
07 Jan 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 1494-1498

Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization

W. Sun, X. Ma, Y. Pang, L. Zhao, Q. Zhong, C. Liu and Q. Fan, RSC Adv., 2022, 12, 1494 DOI: 10.1039/D1RA07944A

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