Palladium-catalyzed stereoselective decarboxylative allylation of azlactones: access to (Z)-trisubstituted allylic amino acid derivatives

Abstract

A palladium-catalyzed stereoselective decarboxylative allylation of azlactones with vinyl methylene cyclic carbonates (VMCCs) as allyl precursors is developed. This method allows the formation of a series of trisubstituted allylic amino acid derivatives under mild conditions in good yields with an exclusive (Z)-configuration. Meanwhile, an alternative protocol by using the in situ generated azlactones for reacting with VMCCs was also exploited to prepare the same type of amino acid derivatives.