Cu(i)- and Pd(ii)-catalyzed decarboxylative cross-couplings of alkynyl carboxylic acids with N-tosylhydrazones: access to trisubstituted allenes and conjugated enynes

Abstract

We report herein the copper- and palladium-catalyzed decarboxylative cross-coupling reactions of alkynyl carboxylic acids and N-tosylhydrazones, affording trisubstituted allenes and conjugated enynes, respectively. With readily available alkynyl carboxylic acids as the acetylene surrogates, the new strategies are operationally simple and show good functional group tolerance.