Synthesis of γ-amino acids via photocatalyzed intermolecular carboimination of alkenes

Abstract

Primary γ-amino acids are essential structural scaffolds with biological activity in pharmaceutical compounds. However, their preparation from readily available substrates remains challenging. Here, we report a direct approach to achieve the energy transfer-driven carboimination of alkenes for the synthesis of a diverse collection of valuable γ-amino acids. Additionally, a variety of γ-lactam derivatives are produced in only two steps from the simple substrates. Furthermore, this transformation features mild reaction conditions, operational simplicity, and excellent functional group tolerance.