Vibsanoids A–D, four new subtypes of vibsane diterpenoids with a distinctive tricyclo[8.2.1.02,9]tridecane core from Viburnum odoratissimum

Abstract

Four highly rearranged tetranorvibsane-type diterpenoids, vibsanoids A–D (1–4), were isolated from the leaves of Viburnum odoratissimum with a molecular networking strategy. Compounds 1–4 represented a new vibsane diterpenoid subtype possessing a tricyclo[8.2.1.0^2,9]tridecane skeleton, which was constructed from an eight-membered ring fused with a bicyclo[2.2.1]heptane moiety via the new C-3–C-10 and C-2–C-13 bonds. Plausible biosynthetic pathways for 1–4 were proposed. Additionally, the cytotoxic and antineuroinflammatory activities of compounds were also tested.