Asymmetric synthesis of δ-substituted-β-keto esters and β-substituted ketones via carboxyl-assisted site- and enantio-selective addition reactions

Abstract

Carboxyl-assisted site- and enantio-selective additions of polyfunctional nucleophiles to imines and carbonyls were developed, affording δ-substituted-β-keto esters and β-substituted ketones with good yields and enantioselectivities. Besides, short synthetic routes to bioactive molecules were also achieved.