Base-mediated unprecedented tandem cyclization reaction of nitrilimines and sulfur ylides: facile approaches to multifunctionalized pyrazolines

Abstract

An interesting three-component tandem reaction between hydrazonoyl chlorides and α-keto-derived sulfonium salts is reported. Highly substituted pyrazolines were obtained in moderate to excellent yields under mild conditions. Moreover, α-keto-stabilised sulfur ylides served as two-carbon synthons in this tandem [3 + 2] cycloaddition reaction.