Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles†
Abstract
An efficient catalytic methodology for trifluoromethylated allylic alkylation of 3-substituted oxindoles using α-(trifluoromethyl)alkenyl acetates as the trifluoromethyl-containing allylic alkylation partner is described. The reaction proceeds smoothly with the incorporation of Pd(OAc)2 and (R)-BINAP, affording various functionalized trifluoromethyl-containing 3,3′-disubstituted oxindoles with high yields and good enantioselectivities. This report is an extension of our continuous work on the application of α-(trifluoromethyl)alkenyl esters.