Issue 36, 2022

Hyperbranched vs. linear poly(disulfide) for intracellular drug delivery

Abstract

This communication reports comparative studies between amphiphilic hyperbranched and linear poly(disulfide) with regard to their aggregation and glutathione-responsive intracellular drug delivery. Both polymers, having similar hydrophobic and hydrophilic moieties, produce micellar particles of comparable size. However, the hyperbranched polymer micelle exhibits much higher drug loading content and drug loading efficiency compared to the linear polymer. In the presence of glutathione, encapsulated Dox could be released from both aggregates. Cellular uptake is significantly better for the hyperbranched polymer compared to the linear polymer. As a result of these factors, the cell killing efficiency of the doxorubicin entrapped hyperbranched polymer micelle is significantly higher compared to its linear analogue.

Graphical abstract: Hyperbranched vs. linear poly(disulfide) for intracellular drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
11 Jul 2022
Accepted
16 Aug 2022
First published
18 Aug 2022

Polym. Chem., 2022,13, 5188-5192

Hyperbranched vs. linear poly(disulfide) for intracellular drug delivery

S. Bera, R. Barman and S. Ghosh, Polym. Chem., 2022, 13, 5188 DOI: 10.1039/D2PY00896C

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