Issue 45, 2022

Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues

Abstract

Pyrazole is an essential structural component of many pharmaceuticals and agrochemicals. The synthesis of pyrazoles has been a subject of intense research for several decades. Many transformations are now available to conveniently access pyrazoles from readily available starting materials. Conventionally, the synthesis of pyrazoles involves the condensation reaction of hydrazines with 1,3-dicarbonyl compounds or their synthetic equivalents and 1,3-dipolar cycloaddition reactions of diazo compounds with dipolarophiles. The present review provides comprehensive information on the development of synthetic approaches to access pyrazoles via [3 + 2] cycloaddition reactions of diazo compounds and their synthetic equivalents.

Graphical abstract: Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues

Article information

Article type
Review Article
Submitted
20 Oct 2022
Accepted
26 Oct 2022
First published
27 Oct 2022

Org. Biomol. Chem., 2022,20, 8787-8817

Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues

S. P. Chandrasekharan, A. Dhami, S. Kumar and K. Mohanan, Org. Biomol. Chem., 2022, 20, 8787 DOI: 10.1039/D2OB01918C

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