Issue 45, 2022
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines†

Zipei Shen,‡a   Lan Zhou,‡a   Chenggui Wu,b   Qianghui Zhou*ac  and  Hong-Gang Cheng ORCID logo *a  

* Corresponding authors

a Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China
E-mail: qhzhou@whu.edu.cn, hgcheng@whu.edu.cn

b Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, China

c The Institute for Advanced Studies, Wuhan University, Wuhan, China

Abstract

A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[b,d]oxepines is reported. This approach involves direct C–H and C–O bond activation followed by a ring annulation and features readily available starting materials, a broad substrate scope, good step economy and good scalability.

Graphical abstract: Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines

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Article information

DOI
https://doi.org/10.1039/D2OB01720B
Article type
Communication
Submitted
21 Sep 2022
Accepted
31 Oct 2022
First published
02 Nov 2022

Org. Biomol. Chem., 2022,20, 8869-8872

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Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines

Z. Shen, L. Zhou, C. Wu, Q. Zhou and H. Cheng, Org. Biomol. Chem., 2022, 20, 8869 DOI: 10.1039/D2OB01720B

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