The 5-fluoro triazole amino acid scaffold prepared by halogen exchange has been incorporated into peptides. From the X-ray diffraction of the 5-fluoro triazole motif, the main observation was an important localization on one side of the negative potential surface. The fluorine atom reveals a cylindrical shape in its deformation electron density.
J. Laxio Arenas, P. Retailleau, J. Gillet, N. Ghermani, S. Ongeri and B. Crousse, Org. Biomol. Chem., 2022, 20, 8410 DOI: 10.1039/D2OB01716D
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