Issue 39, 2022

A reductive dehalogenative process for chemo- and stereoselective synthesis of 1,3-dienylsulfonyl fluorides

Abstract

A method for the mild and efficient synthesis of 1,3-dienylsulfonyl fluorides was developed via dehalogenation of α-halo-1,3-dienylsulfonyl fluorides in the presence of zinc powder and acetic acid, achieving exclusive chemo- and stereoselectivities. This protocol was successfully applied to the synthesis of heterocyclic dienylsulfonyl fluorides and polyene sulfonyl fluoride.

Graphical abstract: A reductive dehalogenative process for chemo- and stereoselective synthesis of 1,3-dienylsulfonyl fluorides

Supplementary files

Article information

Article type
Communication
Submitted
06 Aug 2022
Accepted
21 Sep 2022
First published
22 Sep 2022

Org. Biomol. Chem., 2022,20, 7776-7780

A reductive dehalogenative process for chemo- and stereoselective synthesis of 1,3-dienylsulfonyl fluorides

Y. Zeng, J. Wang and H. Qin, Org. Biomol. Chem., 2022, 20, 7776 DOI: 10.1039/D2OB01434C

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