De novo synthesis of dimerization-ready flavan unit via intramolecular Pummerer/Friedel–Crafts cascade

Abstract

We describe the de novo synthesis of a dimerization-ready flavan derivative via the Pummerer/Friedel–Crafts cascade. This method allowed facile access to oligomeric proanthocyanidin natural products. The total synthesis of procyanidin B4 was achieved by this strategy.