Transition-metal-catalyzed ortho C–H functionalization of 2-arylquinoxalines

Abstract

Recently, direct C–H bond activation and functionalization has become a prodigious and hot topic among synthetic organic chemists due to its step-economic nature and substantial synthetic versatility. On the other hand, quinoxaline, a fused bicycle of benzene and pyrazine, has omnipresent applications in medicinal-, industrial- and materials chemistry. The presence of the N-1 atom in 2-arylquinoxaline enables chelation formation with a metal catalyst leading to the formation of ortho-substituted products. In this review, all articles related to the ortho C–H bond functionalization of 2-arylquinoxalines published up to May 2022 are highlighted.