Issue 34, 2022

Electrosynthetic C–F bond cleavage


Fluorinated organic compounds are common among pharmaceuticals, agrochemicals and materials. The significant strength of the C–F bond results in chemical inertness that, depending on the context, is beneficial, problematic or simply a formidable synthetic challenge. Electrosynthesis is a rapidly expanding methodology that can enable new reactivity and selectivity for cleavage and formation of chemical bonds. Here, a comprehensive overview of synthetically relevant electrochemically driven protocols for C–F bond activation and functionalization is presented, including photoelectrochemical strategies.

Graphical abstract: Electrosynthetic C–F bond cleavage

Article information

Article type
Review Article
10 Jun 2022
01 Aug 2022
First published
03 Aug 2022
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2022,20, 6707-6720

Electrosynthetic C–F bond cleavage

J. L. Röckl, E. L. Robertson and H. Lundberg, Org. Biomol. Chem., 2022, 20, 6707 DOI: 10.1039/D2OB01080A

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