Xin-Ming Xu, Wenzhong Li, Qiwei Li, Sen Chen, Xuesi Zhang, Bin Yang and Wei-Li Wang
Org. Biomol. Chem., 2022,20, 5566-5574
DOI:
10.1039/D2OB00980C,
Paper
A concise manganese(III)-promoted stereoselective β-phosphorylation of acyclic tertiary enamides and diverse H-phosphine oxides was achieved. This reaction proceeds with absolute E-selectivity in contrast to Z-selectivity obtained in other previous works and affords various E-selective β-phosphorylated tertiary enamides in high efficiency. To the best of our knowledge, this is the first case of E-selective β-phosphorylation of tertiary enamides through C–H functionalization. In addition, the method features broad substrate scope, good functional group compatibility and efficient scale-up.