Issue 25, 2022
From the journal:

Organic & Biomolecular Chemistry

C-Methylation controls the biosynthetic programming of alternapyrone†

Jaiyfungkhong Phakeovilay,a   Witcha Imaram,b   Supachai Vuttipongchaikij,c   Waraporn Bunnak,b   Colin M. Lazarusd  and  Pakorn Wattana-Amorn ORCID logo *ab  

* Corresponding authors

a Interdisciplinary Program in Genetic Engineering and Bioinformatics, Graduate School, Kasetsart University, Bangkok, Thailand
E-mail: fscipwa@ku.ac.th

b Department of Chemistry, Special Research Unit for Advanced Magnetic Resonance and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand

c Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand

d School of Biological Sciences, University of Bristol, Bristol, UK

Abstract

Alternapyrone is a highly methylated polyene α-pyrone biosynthesised by a highly reducing polyketide synthase. Mutations of the catalytic dyad residues, H1578A/Q and E1604A, of the C-methyltransferase domain resulted in either significantly reduced or no production of alternapyrone, indicating the importance of C-methylation for alternapyrone biosynthesis.

Graphical abstract: C-Methylation controls the biosynthetic programming of alternapyrone

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Article information

DOI
https://doi.org/10.1039/D2OB00947A
Article type
Communication
Submitted
18 May 2022
Accepted
06 Jun 2022
First published
07 Jun 2022

Org. Biomol. Chem., 2022,20, 5050-5054

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C-Methylation controls the biosynthetic programming of alternapyrone

J. Phakeovilay, W. Imaram, S. Vuttipongchaikij, W. Bunnak, C. M. Lazarus and P. Wattana-Amorn, Org. Biomol. Chem., 2022, 20, 5050 DOI: 10.1039/D2OB00947A

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