Issue 22, 2022

Asymmetric C(sp3)–H borylation: an update

Abstract

Chiral organoboronates have emerged as a key intermediate in the development of pharmaceuticals and materials science. Therefore, several attempts have been made to design various synthetic methods to easily furnish these compounds during the past few decades. Inter alia, asymmetric catalysis has been increasing rapidly as a viable, practical and beneficial strategy for their preparation. In this respect, recent years have witnessed significant progress in aliphatic C–H borylation as the generated carbon–boron bonds are largely utilized to produce other carbon–carbon, carbon–nitrogen and carbon–oxygen bonds. This review presents a detailed overview and analysis of transition metal-catalyzed asymmetric C(sp3)–H borylation strategies. Overall, it assembles all the recent developments in this particular synthetic avenue up to March 2022.

Graphical abstract: Asymmetric C(sp3)–H borylation: an update

Article information

Article type
Review Article
Submitted
13 Apr 2022
Accepted
14 May 2022
First published
16 May 2022

Org. Biomol. Chem., 2022,20, 4496-4511

Asymmetric C(sp3)–H borylation: an update

S. Ghosh, A. Ghosh, P. Pyne and A. Hajra, Org. Biomol. Chem., 2022, 20, 4496 DOI: 10.1039/D2OB00688J

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