The synthetic versatility of fluoroiodomethane: recent applications as monofluoromethylation platform

Abstract

In recent years, fluoroiodomethane (CH₂FI) has emerged as an easy-to-handle, non-ozone depleting agent and readily available platform for monofluoromethylation strategies. Recent applications in nucleophilic substitutions, lithiation reactions, transition-metal catalyzed transformations, radical processes, and ¹⁸F-radiolabelling chemistry showcase the potential of this reagent for the preparation of organofluorine compounds. In this minireview, we provide an update to the field covering the recent relevant literature on the use of CH₂FI.