Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

Abstract

Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary stereocenter.

Graphical abstract: Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2022
Accepted
19 Apr 2022
First published
21 Apr 2022

Org. Biomol. Chem., 2022, Advance Article

Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

W. Peng, Y. Jhang, C. Chang, P. Peng, W. Zhao and Y. Wu, Org. Biomol. Chem., 2022, Advance Article , DOI: 10.1039/D2OB00620K

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