Issue 26, 2022

O-Methylation of carboxylic acids with streptozotocin

Abstract

The clinically used DNA-alkylating drug streptozotocin (STZ) was investigated using a simple work-up as an O-methylating agent to transform various carboxylic acids, sulfonic acids and phosphorous acids into corresponding methyl esters, and did so with yields of up to 97% in 4 h at room temperature. Good substrate tolerance was observed, and benefited from the mild conditions and compatibility of the reaction with water.

Graphical abstract: O-Methylation of carboxylic acids with streptozotocin

Supplementary files

Article information

Article type
Communication
Submitted
28 Mar 2022
Accepted
12 May 2022
First published
13 May 2022

Org. Biomol. Chem., 2022,20, 5230-5233

O-Methylation of carboxylic acids with streptozotocin

L. Zeng, Y. Liu, J. Han, J. Chen, S. Liu and B. Xi, Org. Biomol. Chem., 2022, 20, 5230 DOI: 10.1039/D2OB00578F

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