Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions

Abstract

A convenient and practical synthetic approach for α-ketoamides has been developed under mild conditions. The facile synthesis of α-ketoamides has been accomplished using aryl vinyl azides and secondary amines at room temperature. The inexpensive and readily available iodine and TBHP easily promoted the oxidative amidation process to afford diketoamide derivatives in high yields. This method involves the synthesis of ketoamide compounds via sequential C–O and C–N bond formation. Moreover, metal-free and aerobic conditions and wide substrate scope are the notable advantages of this protocol.