Issue 17, 2022
From the journal:

Organic & Biomolecular Chemistry

Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts†

Bozhen Gong,a   Haibo Zhu, ORCID logo *a   Liu Yang,a   Haifeng Wang,*ab   Qiangwen Fan, ORCID logo ac   Zongbo Xie ORCID logo a  and  Zhanggao Le*a  

* Corresponding authors

a Jiangxi Province Key Laboratory of Synthetic Chemistry, School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang, China
E-mail: hbzhu@ecut.edu.cn, skytacle@139.com, zhgle@ecut.edu.cn

b Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China

c Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang, China

Abstract

An efficient and concise method for the synthesis of diverse substituted sulfones was developed with high selectivity. Using n-PrOH as the solvent, diaryl sulfones are formed even on a gram scale via metal-free coupling from sulfonyl hydrazines with symmetrical or unsymmetrical diaryliodonium salts.

Graphical abstract: Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts

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Article information

DOI
https://doi.org/10.1039/D2OB00389A
Article type
Communication
Submitted
24 Feb 2022
Accepted
07 Apr 2022
First published
08 Apr 2022

Org. Biomol. Chem., 2022,20, 3501-3505

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Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts

B. Gong, H. Zhu, L. Yang, H. Wang, Q. Fan, Z. Xie and Z. Le, Org. Biomol. Chem., 2022, 20, 3501 DOI: 10.1039/D2OB00389A

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