Issue 15, 2022

Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview

Abstract

Indoles are one of the most prominent aromatic heterocycles in the organic chemistry field. Due to their widespread presence in various natural products, alkaloids, drugs, approved medicines, etc. the synthesis and functionalization of indoles are of great interest. This review emphasizes recent developments and techniques in the domino cascade cyclization process in the last decade starting from the various building blocks. In particular, this review depicts several intriguing benzannulation methods of creating a benzene ring on a pre-existing pyrrole nucleus in an inter/intramolecular fashion under metal-catalyzed/metal-free approaches. Different subsections focus on gradual timely developments in this complementary area and a detailed analysis of the mechanisms and reactivity patterns. As a complementary method, this review gives a significant incentive to various annulation strategies and also gives an overview of the remaining challenges and upcoming possibilities.

Graphical abstract: Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview

Article information

Article type
Review Article
Submitted
29 Jan 2022
Accepted
14 Mar 2022
First published
14 Mar 2022

Org. Biomol. Chem., 2022,20, 3029-3042

Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview

S. Sahu, A. Banerjee, S. Kundu, A. Bhattacharyya and M. S. Maji, Org. Biomol. Chem., 2022, 20, 3029 DOI: 10.1039/D2OB00187J

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