Issue 8, 2022

MnSO4-promoted S–O bond cleavage for synthesizing functionalized sulfonium ylides from activated alkynes and sulfoxides

Abstract

A variety of functionalized sulfonium ylides were prepared in good yields through MnSO4-promoted S–O bond cleavage from activated alkynes and sulfoxides. Experimental results showed that the MnSO4 catalyst played important roles in accelerating the reaction and promoting the [1,3]-rearrangement of the S–O bond. Furthermore, the product was easily obtained on a gram scale by simple recrystallization without column chromatography. The obtained product can be converted to new sulfonium ylides and undergo cycloaddition with an alkyne to afford a trisubstituted furan scaffold.

Graphical abstract: MnSO4-promoted S–O bond cleavage for synthesizing functionalized sulfonium ylides from activated alkynes and sulfoxides

Supplementary files

Article information

Article type
Communication
Submitted
26 Dec 2021
Accepted
01 Feb 2022
First published
02 Feb 2022

Org. Biomol. Chem., 2022,20, 1656-1661

MnSO4-promoted S–O bond cleavage for synthesizing functionalized sulfonium ylides from activated alkynes and sulfoxides

W. Chen, Z. Liu, Y. Wang, X. Ma and D. Mo, Org. Biomol. Chem., 2022, 20, 1656 DOI: 10.1039/D1OB02491D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements