Issue 1, 2022

A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Abstract

Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO3-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl and t-Butyl protecting groups.

Graphical abstract: A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2021
Accepted
30 Nov 2021
First published
01 Dec 2021

Org. Biomol. Chem., 2022,20, 106-112

A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

M. Menti-Platten, J. R. Aldrich-Wright and C. P. Gordon, Org. Biomol. Chem., 2022, 20, 106 DOI: 10.1039/D1OB02179F

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