Tosyl/pyrrolyl-capped 1,3-enynes via t-BuOK-assisted reaction of TosMIC with acylethynylpyrroles: a new feature of this popular reagent†
Abstract
1-Tosyl-4-pyrrolyl-1,3-enynes have been synthesized in 37–68% yields by t-BuOK-assisted chemo selective reaction (reflux in THF, 1 h) of 2-(acylethynyl)pyrroles with tosylmethylisocyanide (TosMIC), a widespread reagent, which here manifests a new functionality.