Issue 12, 2022

Total synthesis of myristinins A–F and 3′-hydroxy-5,7-dimethoxy-4-O-2′-cycloflavan by iterative generation of o-quinone methides

Abstract

An iterative generation of o-quinone methides (o-QMs) and [4+2] cycloaddition followed by inter/intra-molecular Michael addition in a cascade sequence gave expedient access to total synthesis of myristinins A–F and 3′-hydroxy-5,7-dimethoxy-4-O-2′-cycloflavan and their analogues, respectively. This cascade sequence cyclisation successfully provided the shortest route to the gram-scale synthesis of the myristinin family, including the first total synthesis of myristinin D–F and 3′-hydroxy-5,7-dimethoxy-4-O-2′-cycloflavan.

Graphical abstract: Total synthesis of myristinins A–F and 3′-hydroxy-5,7-dimethoxy-4-O-2′-cycloflavan by iterative generation of o-quinone methides

Supplementary files

Article information

Article type
Communication
Submitted
16 Jan 2022
Accepted
20 Feb 2022
First published
22 Feb 2022

New J. Chem., 2022,46, 5460-5463

Total synthesis of myristinins A–F and 3′-hydroxy-5,7-dimethoxy-4-O-2′-cycloflavan by iterative generation of o-quinone methides

S. J. Gharpure, S. Jegadeesan and D. S. Vishwakarma, New J. Chem., 2022, 46, 5460 DOI: 10.1039/D2NJ00244B

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