Issue 24, 2022

Construction of photo-induced zinc-doped carbon dots based on drug-resistant bactericides and their application for local treatment

Abstract

In this project, we propose a highly effective photosensitizer that breaks through drug-resistant bacterial infections with zinc-doped carbon dots. By passing through the membrane of drug-resistant bacteria, the photosensitizers produce ROS in bacteria under the action of blue light to directly kill bacteria, so as to realize the antibacterial local treatment of drug-resistant bacteria. The experiment firstly uses an efficient one-step hydrothermal method to prepare zinc-doped red-light CDs as photosensitizers, in which zinc metal was doped to improve the optical properties of the CDs. Then we try first to use EDTA as a second-step attenuator for preparing CDs to obtain photosensitizers with high-efficiency and low toxicity. In vitro cytotoxicity tests, bacterial effect tests, and in vivo animal experiments have also demonstrated that this antibacterial method has great potential for clinical translation, with a bactericidal efficiency of up to 90%. More notably, we used this antibacterial regimen seven times repeatedly to simulate the bacterial resistance process, with a bactericidal efficiency of up to 90% every time. The result indicated that S. aureus did not develop resistance to our method, showing that our method has the potential to break through drug-resistant bacterial infections as an alternative to antibiotic candidates.

Graphical abstract: Construction of photo-induced zinc-doped carbon dots based on drug-resistant bactericides and their application for local treatment

Supplementary files

Article information

Article type
Paper
Submitted
14 Jun 2022
Accepted
18 Oct 2022
First published
04 Nov 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 5365-5377

Construction of photo-induced zinc-doped carbon dots based on drug-resistant bactericides and their application for local treatment

Z. Zhong, Y. Zhang, X. Fu, S. Liu, C. Zhang, W. Guo, X. Xu and L. Liao, Nanoscale Adv., 2022, 4, 5365 DOI: 10.1039/D2NA00375A

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