A multi-omics study of the anti-cancer effect of a ferulic acid derivative FA-30

Dongyao Wang; Dandan Guo; Yuxiao Tang; Minyu Qi; Jiahao Fang; Ying Zhang; Yifeng Chai; Yan Cao; Diya Lv

doi:10.1039/D2MO00025C

A multi-omics study of the anti-cancer effect of a ferulic acid derivative FA-30†

Dongyao Wang,

‡^a Dandan Guo,‡^a Yuxiao Tang,‡^b Minyu Qi,^a Jiahao Fang,^a Ying Zhang,^a Yifeng Chai,*^a Yan Cao*^a and Diya Lv

*^a

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* Corresponding authors

^a Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, Shanghai, China
E-mail: lvdy2020@smmu.edu.cn, caoyan@smmu.edu.cn, yfchai@smmu.edu.cn

^b Department of nutrition, Second Military Medical University, Shanghai, China

Abstract

The active ingredients of Traditional Chinese Medicine are an important source of bioactive molecules and play an important role in the research and development of innovative drugs. FA-30, which is a derivative of natural product ferulic acid, inhibited cervical cancer cell proliferation and induced apoptosis as well. To understand the underlying mechanisms of FA-30, a complementary multi-omics study was conducted. Cysteine and methionine metabolism and aminoacyl-tRNA biosynthesis pathways were significantly changed both at the metabolic level and proteomic level. This may help us to get a better understanding of cervical cancer and FA-30 at the same time.

Molecular Omics

A multi-omics study of the anti-cancer effect of a ferulic acid derivative FA-30†

Abstract

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