Issue 6, 2022

Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

Abstract

New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants.

Graphical abstract: Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
16 Nov 2021
Accepted
21 Apr 2022
First published
21 Apr 2022
This article is Open Access
Creative Commons BY license

Mater. Horiz., 2022,9, 1727-1734

Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

J. Gurke, T. E. Naegele, S. Hilton, R. Pezone, V. F. Curto, D. G. Barone, E. J. W. List-Kratochvil, A. Carnicer-Lombarte and G. G. Malliaras, Mater. Horiz., 2022, 9, 1727 DOI: 10.1039/D1MH01855H

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