Issue 12, 2022

Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review

Abstract

Thanks to the developments in the area of microfluidics, the cavitation-on-a-chip concept enabled researchers to control and closely monitor the cavitation phenomenon in micro-scale. In contrast to conventional scale, where cavitation bubbles are hard to be steered and manipulated, lab-on-a-chip devices provide suitable platforms to conduct smart experiments and design reliable devices to carefully harness the collapse energy of cavitation bubbles in different bio-related and industrial applications. However, bubble behavior deviates to some extent when confined to micro-scale geometries in comparison to macro-scale. Therefore, fundamentals of micro-scale cavitation deserve in-depth investigations. In this review, first we discussed the physics and fundamentals of cavitation induced by tension-based as well as energy deposition-based methods within microfluidic devices and discussed the similarities and differences in micro and macro-scale cavitation. We then covered and discussed recent developments in bio-related applications of micro-scale cavitation chips. Lastly, current challenges and future research directions towards the implementation of micro-scale cavitation phenomenon to emerging applications are presented.

Graphical abstract: Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review

Article information

Article type
Critical Review
Submitted
21 Feb 2022
Accepted
25 Apr 2022
First published
02 May 2022

Lab Chip, 2022,22, 2237-2258

Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review

S. Seyedmirzaei Sarraf, F. Rokhsar Talabazar, I. Namli, M. Maleki, A. Sheibani Aghdam, G. Gharib, D. Grishenkov, M. Ghorbani and A. Koşar, Lab Chip, 2022, 22, 2237 DOI: 10.1039/D2LC00169A

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