Issue 10, 2022

Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry


The possibility of harnessing the photoactivity of isocyanides in the development of metal-free Ugi-like visible light photo-triggered multicomponent transformations has been reported herein. More in detail, Ugi-3CR, Ugi-Tetrazole-3CR, and Ugi–Joullié-3CR afforded imide peptidomimetic derivatives in good yields and with a wide substrate scope, involving the late-stage editing of complex bioactive scaffolds. Furthermore, a 2-step-one-pot sequence affording linear secondary imides, and a 3-step-one-pot protocol leading to densely functionalized bis-amide derivatives have also been developed to highlight the huge potential of these mild metal-free reaction conditions to afford complex and diverse compounds while being in accordance with the green chemistry principles.

Graphical abstract: Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry

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Article information

Article type
04 Mar 2022
19 Apr 2022
First published
20 Apr 2022
This article is Open Access
Creative Commons BY license

Green Chem., 2022,24, 3993-4003

Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry

C. Russo, G. Graziani, R. Cannalire, G. C. Tron and M. Giustiniano, Green Chem., 2022, 24, 3993 DOI: 10.1039/D2GC00855F

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